Proteomics Research
in La Jolla
The Yates Laboratory at Scripps Research develops and applies mass spectrometry-based proteomics to answer basic biological questions. Based in La Jolla, California, our work spans method development, bioinformatics, and a range of biological applications.
Led by Dr. John R. Yates III, Ernest W. Hahn Professor in the Departments of Molecular Medicine and Neurobiology, our lab pioneered landmark advances including the SEQUEST database search algorithm, Multidimensional Protein Identification Technology (MudPIT), and the Census quantification platform.
With 1,532 publications and 150,312 citations, the lab has worked in proteomics for more than three decades, building methods to measure more of what happens in complex biological systems.
What We Study
Six areas of research across the lab
Method Development
Developing new mass spectrometry methods
We develop mass spectrometric methods and technologies that improve the sensitivity, resolution, accuracy, and speed of proteomic experiments. Our contributions...
Bioinformatics & Software
Software for analyzing proteomics data
We develop computational tools and algorithms for analyzing large-scale MS-based proteomics datasets. From the SEQUEST database search algorithm to DTASelect an...
Post-Translational Modifications
Characterizing protein modifications
We employ targeted and global proteomics approaches to characterize post-translational modifications (PTMs) including phosphorylation, ubiquitination, acetylati...
Supported By
Join Us in La Jolla
We are always looking for scientists interested in proteomics, mass spectrometry, and computational biology. Come work with us. The ocean is right outside.